Title: Research Associate III, Antibody Discovery & Engineering

Location: Onsite

Start date: ASAP

Pay Rate Range: $40-43/hr

We are seeking a collaborative and independent Research Associate III (RA III) to participate in development of antibody-based oncology therapeutics. The RA III will report to the Molecular and Cellular Technologies team lead within Antibody Discovery. Their primary responsibilities will include engineering cell lines and performing flow-based assays to support antibody campaigns. The successful candidate will work well in a highly collaborative team environment and possess expertise in flow cytometry, mammalian cell culture, and cell engineering.

Responsibilities

• Design, execute, troubleshoot, optimize, and interpret experiments

• Order constructs for overexpression and knockout cell line generation

• Engineer cell lines using transfection, nucleofection, CRISPR/Cas9, lentiviral transduction, and other methodologies

• Evaluate target expression on engineered and endogenous cell lines using flow cytometry and molecular characterization

• Perform routine cell culture maintenance and banking, working with both primary and cancer cells

• Optimize and perform flow cytometry assays to screen and characterize antibodies

• Maintain laboratory spaces, equipment, and supplies

• Keep an up-to-date and accurate electronic laboratory notebook

• Present experimental findings and contribute to scientific discussion at group and cross-functional team meetings

• Proactively seek guidance and build knowledge relevant to the role

Required Qualifications

• Bachelors degree + 4 years laboratory research experience or Masters degree + 2 years laboratory research experience in biological sciences or related subject

• Proficiency in culturing/maintaining multiple cell lines under BSL2 conditions

• Knowledge of cell engineering platforms, including transient transfection, generation of stable cell lines, and CRISPR

• Experience in multi-color flow cytometry

• Demonstrated ability to work independently and collaboratively, according to project needs

• Strong written and verbal communication skills, including ability to maintain a good working laboratory notebook

Preferred Qualifications

• Experience with FACS and single-cell cloning

• Basic molecular biology skills, including vector design, cloning, and PCR

• Knowledge of antibodies or antibody drug conjugates (ADCs)

Benefits

System One offers eligible employees health and welfare benefits coverage options, including medical, dental, vision, spending accounts, life insurance, voluntary plans, and participation in a 401(k) plan.

System One, and its subsidiaries including Joulé, ALTA IT Services, CM Access, TPGS, and MOUNTAIN, LTD., are leaders in delivering workforce solutions and integrated services across North America. We help clients get work done more efficiently and economically, without compromising quality. System One not only serves as a valued partner for our clients, but we offer eligible full-time employees health and welfare benefits coverage options including medical, dental, vision, spending accounts, life insurance, voluntary plans, as well as participation in a 401(k) plan.

System One is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity, age, national origin, disability, family care or medical leave status, genetic information, veteran status, marital status, or any other characteristic protected by applicable federal, state, or local law.